Epoetin theta
Biopoin, Eporatio (epoetin theta) is a protein pharmaceutical. Epoetin theta was first approved as Biopoin on 2009-10-23. It has been approved in Europe to treat anemia, chronic kidney failure, and neoplasms.
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635 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | HP_0001903 | D64.9 | 8 | 87 | 140 | 65 | 60 | 355 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 3 | 23 | 47 | 16 | 27 | 116 |
| Chronic renal insufficiency | D051436 | — | N18 | 5 | 20 | 50 | 16 | 23 | 114 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 4 | 12 | 22 | 12 | 8 | 57 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | 3 | 11 | 20 | 9 | 9 | 52 |
| Neoplasms | D009369 | — | C80 | — | 14 | 15 | 5 | 10 | 44 |
| Syndrome | D013577 | — | — | 2 | 21 | 8 | 3 | 4 | 35 |
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 20 | 9 | 2 | 4 | 34 |
| Preleukemia | D011289 | — | — | 2 | 19 | 9 | 2 | 4 | 33 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 6 | — | 4 | 8 | 19 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | — | 7 | 7 | — | 1 | 15 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | 6 | 4 | — | 5 | 14 |
| Multiple myeloma | D009101 | — | C90.0 | — | 2 | 7 | — | 4 | 13 |
| Brain injuries | D001930 | — | S06.9 | — | 6 | 5 | — | 1 | 10 |
| Plasma cell neoplasms | D054219 | — | — | — | 2 | 6 | — | 2 | 10 |
| Brain diseases | D001927 | HP_0001298 | G93.40 | 5 | 3 | 5 | — | — | 10 |
| Blood transfusion | D001803 | — | — | — | 4 | 5 | — | 4 | 10 |
| Plasmacytoma | D010954 | — | C90.3 | — | 2 | 5 | — | 1 | 8 |
| Brain ischemia | D002545 | EFO_0003883 | I67.82 | 5 | 3 | 3 | — | — | 8 |
| Brain hypoxia-ischemia | D020925 | EFO_1000846 | P91.6 | 5 | 3 | 3 | — | — | 8 |
Show 95 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 12 | 3 | — | — | 2 | 15 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | 5 | — | — | — | 6 |
| Immunologic deficiency syndromes | D007153 | HP_0002721 | D84.9 | 1 | 5 | — | — | — | 6 |
| Ischemic stroke | D000083242 | — | — | 1 | 5 | — | — | — | 5 |
| Cardiac surgical procedures | D006348 | — | — | 1 | 2 | — | — | 2 | 4 |
| Coronary artery disease | D003324 | — | I25.1 | — | 3 | — | — | — | 3 |
| Reperfusion injury | D015427 | — | — | — | 1 | — | — | 2 | 3 |
| Paralysis | D010243 | HP_0003470 | — | 1 | 1 | — | — | 1 | 3 |
| Replacement arthroplasty knee | D019645 | — | — | — | 1 | — | — | 2 | 3 |
| Chronic disease | D002908 | — | — | — | 2 | — | — | 1 | 3 |
Show 62 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aids-related complex | D000386 | EFO_0007137 | B20 | 1 | — | — | — | 2 | 3 |
| Reticulocyte count | D017701 | — | — | 1 | — | — | — | — | 1 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 1 | — | — | — | — | 1 |
| Autoimmune hepatitis | D019693 | — | — | 1 | — | — | — | — | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | — | — | — | — | 1 |
| Cerebral hemorrhage | D002543 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cytopenia | D000095542 | — | — | — | — | — | — | 9 | 9 |
| Pancytopenia | D010198 | HP_0001876 | D61.81 | — | — | — | — | 8 | 8 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | — | — | — | 2 | 2 |
| Continuous ambulatory peritoneal dialysis | D010531 | — | — | — | — | — | — | 1 | 1 |
| Developmental disabilities | D002658 | EFO_0003852 | F89 | — | — | — | — | 1 | 1 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | — | — | 1 | 1 |
| Iron metabolism disorders | D019189 | — | E83.1 | — | — | — | — | 1 | 1 |
| Body weight | D001835 | EFO_0004338 | — | — | — | — | — | 1 | 1 |
| Scoliosis | D012600 | EFO_0004273 | M41 | — | — | — | — | 1 | 1 |
| Cerebrovascular disorders | D002561 | EFO_0003763 | I60-I69 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Epoetin theta |
| INN | epoetin alfa |
| Description | Epoetin theta, sold under the brand name Biopoin among others, is a copy of the human hormone erythropoietin.
|
| Classification | Protein |
| Drug class | erythropoietins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 762263-14-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108290 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 64FS3BFH5W (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: Epogen, Retacrit
Adverse Events
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33,996 adverse events reported
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